Royal Air Force Typhoon fighter aircraft have conducted a mission with France's air force in a coordinated attack on an hidden munitions depot in Syria operated by the IS group, according to the British defence ministry.
The site, located using reconnaissance, was assessed as storing arms and explosives, the statement said, and was situated in mountainous terrain just above the ancient city of Palmyra in central Syria.
"The RAF jets used laser-guided Paveway IV weapons to target a series of access tunnels leading to the site... initial indications indicate the strike was effective," officials stated.
There was no indication of any civilian casualties in the operation late on Saturday and each participating jet made a safe return, the MoD added.
The Typhoon FGR4s were assisted by a Voyager refuelling tanker.
Daesh - also known as ISIS - imposed extremist governance over large swathes of both Syria and Iraq before its territorial defeat in 2019.
"This action demonstrates our UK leadership, and resolve to stand shoulder to shoulder with allied nations, to stamp out any re-emergence of IS and their harmful and extremist ideologies in the Middle East," Britain's Defence Chief the Defence Secretary stated.
UK warplanes have carried out surveillance missions over Syrian airspace to "prevent any attempted resurgence" of IS subsequent to its defeat at the battle of Baghuz in 2019, the ministry said.
"I extend gratitude to all the members of our armed forces involved in this mission for their expertise and their bravery," the Defence Secretary said. "They were part of thousands of British troops on duty over Christmas and New Year. This action, to take out terrorist threats who pose a risk to our safety, shows how our armed forces are ready to step up, throughout the year, ensuring Britain's security domestically and strong abroad."
Last December, the United States armed forces conducted what it called a "large-scale strike" targeting Daesh sites in the country, following an attack killed two US servicemembers and a local interpreter in the Palmyra area.
The UN reports Islamic State still has between 5,000 and 7,000 fighters in both countries.